Anti-CD130 Mouse Monoclonal Antibody [clone: B-T2]Supplier: GeneTex
89358-100EA 584.82 USD89358-100
Anti-CD130 Mouse Monoclonal Antibody [clone: B-T2]
CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Recommended Starting Dilutions:Flow Cytometry: Max Dilution 0.2ug/106cellsNot tested in other applications. Optimal dilution / concentration should be determined by the end user.
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