Anti-CPB2 Mouse Monoclonal Antibody [clone: 13H4]

Supplier: GeneTex

89350-908EA 387.07 USD
Anti-CPB2 Mouse Monoclonal Antibody [clone: 13H4]
This protein belongs to a family of Zn-containing metallocarboxypeptidases specific to C-terminal lysine and arginine residues. It circulates in plasma as a zymogen with molecular weigh of 55 kDa (401 amino acid residues; pI 5.0, Fig. 32). Being activated by thrombin-thrombomodulin complex during blood coagulation, it exerts carboxypeptidase activity. Activated it removes C-terminal lysine residues from fibrin, which are necessary for plasminogen binding to fibrin. This prevents plasminogen from activation into plasmin and retards the lysis of a fibrin clot. The concentration in plasma of healthy people is 5 10 μg/ml. High plasma levels were found in patients with stable angina pectoris and angiographically verified coronary artery disease. Elevated concentration in blood is considered as a risk factor for venous thrombosis. A deficiency might contribute to the severity of bleeding disorders in hemophilias A and B, and decreased levels are found in chronic liver disease.

ELISA: Use at an assay dependent dilution. EIA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 50.8 kDa. Can be paired for ELISA with this antibody as detection and GTX14756 Mouse monoclonal [13D5] to Carboxypeptidase B2 or GTX14763 Mouse monoclonal [15A10] to Carboxypeptidase B2 as capture. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: CPB2
Clonality: Monoclonal
Clone: 13H4
Conjugation: Unconjugated
Host: Mouse
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