Alx4, a novel paired-like-homeodomain protein, is a transcriptional activation factor whose expression is restricted to sites of epithelial mesenchymal interactions. A negative feedback loop exists between Alx4 and Shh (Sonic hedgehog) during limb outgrowth. The anterior localization of Alx4 in the limb bud is a key factor in determining the correct anteriorposterior axis of the vertebrate limb. Alx4 is expressed on a variety of tissues including: osteoblast precursors, dermal papilla of hair and whisker follicles, dental papilla of teeth, and mesenchymal cells.
WB: Use at a concentration of 1 - 5 ?g/ml. Detects bands of approximately 41 and 43 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: ALX4
Clonality: Monoclonal
Clone: KAB4
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human