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Anti-AIF Rabbit Polyclonal Antibody

Supplier: Genetex
GTX21998
Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins (1). A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF) (2). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli (2,3). AIF is highly conserved between human and mouse and widely expressed (2).

For WB: Use at a dilution of 1:500-1:2,000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

Type: Primary
Antigen: AIF
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μg GTX21998 89361-126 Each (100µG) Retrieving Restricted

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SPECIFICATIONS

Antigen Symbol AIF
Antigen Name Apoptosis inducing factor
Reactivity Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
Antigen Synonyms PDCD8, striatal apoptosis-inducing factor, apoptosis-inducing factor 1, mitochondrial, COXPD6, programmed cell death 8 (apoptosis-inducing factor), AIF, RP3-438D16.2
Gene ID 9131
Concentration 0.5 mg/ml
Immunogen Synthetic peptide - amino acids 517-531 of human AIF. This sequence is identical to those of mouse and rat AIF
Purification Affinity purified with antigen
Storage Buffer Phosphate-buffered saline, pH 7.4 containing 0.02% sodium azide
Storage Temperature Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Tested Applications WB
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